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Phase-I drug interaction study in Crohn’s disease patients initiated

Crohn’s disease is a long-term condition that causes inflammation of the digestive system. Symptoms include abdominal pain, diarrhea, fever and weight loss.
In close collaboration with the Clinic for Gastroenterology, Hepatology and Endocrinology at the Hannover Medical School (Prof. Dr. Ursula Seidler), the potential of ustekinumab to interfere with the pharmacokinetics of midazolam, warfarin, omeprazole, dextromethorphan, and caffeine is being explored at the CRC Hannover in a phase-I study with patients with moderate to severe Crohn’s disease.